Methyl iodide → HCID 24986111, compound

Participants

Reaction Steps

Following the procedure as described in Example 15, making variations only as required to use methyl iodide in place of (bromomethyl)cyclopropane to react with ethyl 2-(4-hydroxy-2-oxopyridin-1(2H)-yl)-4-methylthiazole-5-carboxylate, the title compound was obtained as a yellowish solid in 54% yield: mp 163-165° C. (hexane/ethyl acetate); 1H NMR (300 MHz, CDCl3) δ 8.67 (d, J=8.1 Hz, 1H), 6.16 (dd, J=8.1, 2.7 Hz, 1H), 6.00 (d, J=2.7 Hz, 1H), 4.32 (q, J=7.1 Hz, 2H), 3.83 (s, 3H), 2.68 (s, 3H), 1.36 (t, J=7.1 Hz, 3H); 13C NMR (75 MHz, CDCl3) δ 168.3, 162.9, 162.2, 156.6, 155.7, 131.3, 119.7, 103.8, 96.3, 60.9, 56.0, 17.3, 14.3; MS (ES+) m/z 295.2 (M+1).

Provenance & Evidence