Hydrochloric Acid → HCID 178433082, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of ethyl 2-(4-(benzyloxy)-2-oxopyridin-1(2H)-yl)-4-methyl-1H-imidazole-5-carboxylate (0.10 g, 0.28 mmol) in 1 N aqueous sodium hydroxide (2 mL) was stirred at 45° C. for 16 h, and then at 65° C. for 5 h. The reaction mixture was cooled to 0° C. then acidified with 10% aqueous hydrochloric acid to pH ˜2. The precipitate was filtered, washed with water, and then with acetone into a separate flask. The acetone filtrate was concentrated in vacuo and co-concentrated with methanol to dryness (×2). The residue was combined with the solid to afford the title compound (0.060 g, 65%): MS (ES−) m/z 324.2 (M−1).

Provenance & Evidence