4-(Chloromethyl)-1,3-thiazole → N-Benzyl-4-methyl-2-(2-oxo-4-(thiazol-4-ylmethoxy)pyridin-1(2H)-yl)thiazole-5-carboxamide

참여 물질

반응 단계

Following the procedure as described in Example 21, making variation only as required to use 4-(chloromethyl)thiazole in place of 2-(chloromethyl)-5-phenyl-1,3,4-oxadiazole to react with N-benzyl-2-(4-hydroxy-2-oxopyridin-1(2H)-yl)-4-methylthiazole-5-carboxamide, the title compound was obtained as a colorless solid in 29% yield: 1H NMR (300 MHz, DMSO-d6) δ 9.12 (d, J=1.9 Hz, 1H), 8.79 (t, J=5.9 Hz, 1H), 8.61 (d, J=8.0 Hz, 1H), 7.89 (d, J=1.9 Hz, 1H), 7.33-7.27 (m, 4H), 7.25-7.17 (m, 1H), 6.38-6.32 (m, 2H), 5.27 (s, 2H), 4.38 (d, J=5.9 Hz, 2H), 2.54 (s, 3H); MS (ES+) m/z 439.1 (M+1).

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