3-(Bromomethyl)-5-methylisoxazole → HCID 57744460, compound

Participants

Reaction Steps

Following the procedure as described in Example 21, making variation only as required to use 3-(bromomethyl)-5-methylisoxazole in place of 2-(chloromethyl)-5-phenyl-1,3,4-oxadiazole to react with N-benzyl-2-(4-hydroxy-2-oxopyridin-1(2H)-yl)-4-methylthiazole-5-carboxamide, the title compound was obtained as a colorless solid in 47% yield: 1H NMR (300 MHz, DMSO-d6) δ 8.79 (t, J=5.9 Hz, 1H), 8.62 (d, J=8.1 Hz, 1H), 7.35-7.18 (m, 5H), 6.38-6.35 (m, 2H), 6.26 (d, J=2.6 Hz, 1H), 5.22 (s, 2H), 4.38 (d, J=5.9 Hz, 2H), 2.54 (s, 3H), 2.38 (s, 3H); MS (ES+) m/z 437.2 (M+1).

Provenance & Evidence