2-(Bromomethyl)-1,3-benzothiazole → HCID 57744471, compound

Participants

Reaction Steps

Following the procedure as described in Example 21, making variation only as required to use 2-(bromomethyl)benzo[d]thiazole in place of 2-(chloromethyl)-5-phenyl-1,3,4-oxadiazole to react with N-benzyl-2-(4-hydroxy-2-oxopyridin-1(2H)-yl)-4-methylthiazole-5-carboxamide, the title compound was obtained as a colorless solid in 14% yield: 1H NMR (300 MHz, DMSO-d6) δ 8.79 (t, J=5.9 Hz, 1H), 8.66 (d, J=8.1 Hz, 1H), 8.13-8.11 (m, 1H), 8.03-8.00 (m, 1H), 7.55-7.42 (m, 2H), 7.34-7.18 (m, 5H), 6.48 (dd, J=8.1, 2.7 Hz, 1H), 6.34 (d, J=2.7 Hz, 1H), 5.68 (s, 2H), 4.38 (d, J=5.9 Hz, 2H), 2.54 (s, 3H); MS (ES+) m/z 489.1 (M+1).

Provenance & Evidence