4-(Chloromethyl)-2-isopropyl-1,3-thiazole → HCID 57744513, compound

Participants

Reaction Steps

Following the procedure as described in Example 21, making variation only as required to use 4-(chloromethyl)-2-isopropylthiazole in place of 2-(chloromethyl)-5-phenyl-1,3,4-oxadiazole to react with N-benzyl-2-(4-hydroxy-2-oxopyridin-1(2H)-yl)-4-methylthiazole-5-carboxamide, the title compound was obtained as a colorless solid in 36% yield: 1H NMR (300 MHz, CDCl3) δ 8.67 (d, J=8.1 Hz, 1H), 7.34-7.23 (m, 5H), 7.21 (s, 1H), 6.28-6.20 (m, 1H), 6.10-6.04 (m, 2H), 5.12 (s, 2H), 4.59 (d, J=5.6 Hz, 2H), 3.38-3.27 (m, 1H), 2.68 (s, 3H), 1.45-1.35 (m, 6H); MS (ES+) m/z 481.2 (M+1).

Provenance & Evidence