2-Chloro-5-(chloromethyl)pyridine → HCID 57744456, compound

Participants

Reaction Steps

Following the procedure as described in Example 21, making variation only as required to use 2-chloro-5-(chloromethyl)pyridine in place of 2-(chloromethyl)-5-phenyl-1,3,4-oxadiazole to react with N-benzyl-2-(4-hydroxy-2-oxopyridin-1(2H)-yl)-4-methylthiazole-5-carboxamide, the title compound was obtained as a colorless solid in 73% yield: 1H NMR (300 MHz, DMSO-d6) δ 8.79 (t, J=5.9 Hz, 1H), 8.62 (d, J=8.1 Hz, 1H), 8.51 (d, J=2.4 Hz, 1H), 7.95 (dd, J=8.3, 2.5 Hz, 1H), 7.57-7.54 (m, 1H), 7.35-7.16 (m, 5H), 6.39 (dd, J=8.1, 2.7 Hz, 1H), 6.26 (d, J=2.7 Hz, 1H), 5.22 (s, 2H), 4.38 (d, J=5.9 Hz, 2H), 2.54 (s, 3H); MS (ES+) m/z 467.0 (M+1).

Provenance & Evidence