4-(Chloromethyl)-2-methyl-1,3-thiazole → HCID 57744467, compound

Participants

Reaction Steps

Following the procedure as described in Example 21, making variation only as required to use 4-(chloromethyl)-2-methylthiazole in place of 2-(chloromethyl)-5-phenyl-1,3,4-oxadiazole to react with N-benzyl-2-(4-hydroxy-2-oxopyridin-1(2H)-yl)-4-methylthiazole-5-carboxamide, the title compound was obtained as a colorless solid in 20% yield: 1H NMR (300 MHz, CDCl3) δ 8.67 (d, J=8.1 Hz, 1H), 7.34-7.26 (m, 5H), 7.20 (s, 1H), 6.24 (dd, J=8.1, 2.7 Hz, 1H), 6.13-6.07 (m, 2H), 5.10 (s, 2H), 4.59 (d, J=5.6 Hz, 2H), 2.73 (s, 3H), 2.67 (s, 3H); MS (ES+) m/z 453.1 (M+1).

Provenance & Evidence