2-Aminoindane → HCID 57744476, compound

Participants

Reaction Steps

Following the procedure as described in Example 22, making variation only as required to use 2,3-dihydro-1H-inden-2-amine in place of benzo[b]thiophen-2-ylmethanamine to react with 2-(4-(benzyloxy)-2-oxopyridin-1(2H)-yl)-4-methylthiazole-5-carboxylic acid, the title compound was obtained as a colorless solid in 27% yield: 1H NMR (300 MHz, DMSO-d6) δ 8.61 (d, J=8.1 Hz, 1H), 8.51 (d, J=7.0 Hz, 1H), 7.50-7.31 (m, 5H), 7.20-7.09 (m, 4H), 6.38 (dd, J=8.1, 2.7 Hz, 1H), 6.22 (d, J=2.7 Hz, 1H), 5.15 (s, 2H), 4.66-4.58 (m, 1H), 3.24-3.11 (m, 2H), 2.95-2.84 (m, 2H), 2.52 (s, 3H); MS (ES+) m/z 458.2 (M+1).

Provenance & Evidence