(1-methyl-1H-pyrazol-4-yl)methanamine → HCID 57744487, compound

Participants

Reaction Steps

Following the procedure as described in Example 22, making variation only as required to use (1-methyl-1H-pyrazol-4-yl)methanamine in place of benzo[b]thiophen-2-ylmethanamine to react with 2-(4-(benzyloxy)-2-oxopyridin-1(2H)-yl)-4-methylthiazole-5-carboxylic acid, the title compound was obtained as a colorless solid in 8% yield: 1H NMR (300 MHz, DMSO-d6) δ 8.59 (d, J=8.1 Hz, 1H), 8.31 (br s, 2H), 7.69 (s, 1H), 7.50-7.30 (m, 5H), 6.30 (dd, J=8.1, 2.7 Hz, 1H), 6.13 (d, J=2.7 Hz, 1H), 5.13 (s, 2H), 3.82 (s, 2H), 3.77 (s, 3H), 2.52 (s, 3H); MS (ES+) m/z 436.1 (M+1).

Provenance & Evidence