(2-Methylthiazol-4-yl)MethanaMine → 2-(4-(Benzyloxy)-2-oxopyridin-1(2H)-yl)-4-methyl-N-((2-Methylthiazol-4-yl)methyl)thiazole-5-carboxamide

Participants

Reaction Steps

Following the procedure as described in Example 25, making variation only as required to use (2-methylthiazol-4-yl)methanamine in place of benzo[b]thiophen-2-ylmethanamine to react with 2-(4-(benzyloxy)-2-oxopyridin-1(2H)-yl)-4-methylthiazole-5-carboxylic acid, the title compound was obtained as a colorless solid in 74% yield: 1H NMR (300 MHz, DMSO-d6) δ 8.74 (t, J=5.7 Hz, 1H), 8.61 (d, J=8.1 Hz, 1H), 7.45-7.31 (m, 5H), 7.16 (s, 1H), 6.38 (dd, J=8.1, 2.7 Hz, 1H), 6.23 (d, J=2.7 Hz, 1H), 5.16 (s, 2H), 4.42 (d, J=5.7 Hz, 2H), 2.59 (s, 3H), 2.54 (s, 3H); MS (ES+) m/z 453.1 (M+1).

Provenance & Evidence