5-(Aminomethyl)-2-(trifluoromethyl)pyridine → HCID 57744473, compound

Participants

Reaction Steps

Following the procedure as described in Example 22, making variation only as required to use (6-(trifluoromethyl)pyridin-3-yl)methanamine in place of benzo[b]thiophen-2-ylmethanamine to react with 2-(4-(benzyloxy)-2-oxopyridin-1(2H)-yl)-4-methylthiazole-5-carboxylic acid, the title compound was obtained as a colorless solid in 38% yield: 1H NMR (300 MHz, DMSO-d6) δ 8.89 (t, J=5.6 Hz, 1H), 8.69 (br s, 1H), 8.61 (d, J=8.1 Hz 1H), 7.98-7.96 (m, 1H), 7.87-7.84 (m, 1H), 7.45-7.33 (m, 5H), 6.39 (dd, J=8.1, 2.6 Hz, 1H), 6.23 (d, J=2.6 Hz, 1H), 5.16 (s, 2H), 4.50 (d, J=5.6 Hz, 2H), 2.54 (s, 3H); MS (ES+) m/z 501.1 (M+1).

Provenance & Evidence