HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dibromodifluoromethane → tert-butyl((3R,3aS,6aR)-6-(difluoromethylene)hexahydrofuro[3,2-b]furan-3-yloxy)dimethylsilane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dibromodifluoromethane | HCID 6382 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | (3aS,6R,6aS)-6-(tert-butyldimethylsilyloxy)tetrahydrofuro[3,2-b]furan-3(2H)-one | HCID 67049238 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | tert-butyl((3R,3aS,6aR)-6-(difluoromethylene)hexahydrofuro[3,2-b]furan-3-yloxy)dimethylsilane | HCID 67048710 | — |
Reaction Steps
Alternatively, ketone (87) may be treated with triphenylphosphine and dibromodifluoromethane in N,N-dimethylacetamide to give tert-butyl((3R,3aS,6aR)-6-(difluoromethylene)hexahydrofuro[3,2-b]furan-3-yloxy)dimethylsilane (97) as detailed in Scheme 8.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08501744B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-3d975287d4274560872fc2805304209d |
| Source note | uspto-grants-2013_08 |