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HRID1887390

反应详情

EQUATION

反应方程式

HRID 1887390 的结构方程式

REACTANTS

反应物

2
结构：C1COCCO1.Cl
HCID20443148

1,4-Dioxane hydrochloride

C4H9ClO2

结构：CC(C)(C)OC(=O)N1C[C@H](Br)[C@H]2OC[C@H](O)[C@H]21
HCID58208606

未命名化合物

PRODUCTS

生成物

1
结构：Cl.O[C@H]1CO[C@H]2[C@@H]1NC[C@@H]2Br
HCID67048907

未命名化合物

PROCEDURE

实验过程

Bromide (111) (2.14 g, 6.95 mmol) was dissolved in 4N HCl/dioxan (30 mL) with stirring at ambient temperature. The purple solution was stirred for 1 hour then reduced in vacuo and evaporated three times from diethyl ether to give a purple crystalline solid crude (3R,3aR,6S,6aS)-6-bromohexahydro-2H-furo[3,2-b]pyrrol-3-ol hydrochloride (112) (Yield 1730 mg) which was used without further purification. HPLC-MS 208.0/210.0 [M+H]+.

WORKUP

后处理

  1. stirringThe purple solution was stirred for 1 hour
  2. customevaporated three times from diethyl ether