Hydrochloric Acid → HCID 59586841, compound

Participants

Reaction Steps

To a solution of tert-butyl 4-chloro-5,8-dihydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidine-7(6H)-carboxylate (3500 mg, 10.7 mmol) in THF (100 mL) was added 4 N HCl in 1,4-dioxane (4 N, 6 mL). The reaction mixture was stirred at room temperature for 24 h. The white precipitate was collected and dried under reduced pressure and gave 2000 mg (82%) of the desired product. LCMS RT=0.21 min, [M+1]+=226.

Provenance & Evidence