HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (3,4-Dichloro-phenyl)-(5,6,7,8-tetrahydro-9-thia-1,3,7-triaza-fluoren-4-yl)-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 3,4-Dichloroaniline | HCID 7257 | — |
| Reactant | tert-Butyl 4-chloro-5,6-dihydropyrido(4',3':4,5)thieno(2,3-d)pyrimidine-7(8H)-carboxylate | HCID 49788563 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (3,4-Dichloro-phenyl)-(5,6,7,8-tetrahydro-9-thia-1,3,7-triaza-fluoren-4-yl)-amine | HCID 58116912 | 77.6% |
Reaction Steps
Following the same procedure as described in Example 7, step 1 using 4-Chloro-5,8-dihydro-6H-9-thia-1,3,7-triaza-fluorene-7-carboxylic acid tert-butyl ester (3.5 g, 0.011 mol), 3,4-dichloroaniline (1.9 g, 0.012 mol), 4 N HCl in Dioxane (1.3 ml) in 2-propanol (72 ml) and gave the desired product (3.0 g, 72%). LCMS RT=2.77 min, [M+H]+=351.8.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08501755B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-704a297a99b542929a689df38134b0e5 |
| Source note | uspto-grants-2013_08 |