Diisopropylethylamine → HCID 70233351, compound

Participants

Reaction Steps

PyBOP (74.5 mg) was added to a solution of the compound 10 obtained in Example 3 (25.0 mg), N,N-diisopropylethylamine (0.0624 ml) and 5-cyanopyridine-2-carboxylic acid (Compound 9-3) (16.9 mg) in dichloromethane (5.0 ml) at room temperature. The mixture was stirred at room temperature for one hour. The reaction solution was poured into aqueous sodium bicarbonate, followed by extraction with ethyl acetate. The extract was washed with brine and dried over anhydrous magnesium sulfate. The drying agent was removed by filtration and the filtrate was concentrated under reduced pressure. The crude product was purified by silica gel column chromatography to obtain the title compound (35 mg).

Provenance & Evidence