Potassium Carbonate → HCID 58337657, compound

Participants

Reaction Steps

1-Bromo-3-chloro-5-fluorobenzene (1.0 g, 4.8 mmol, 1.0 eq), 5-hydroxypyrimidine (454 mg, 5.02 mmol, 1.05 eq), K2CO3 (792 mg, 5.73 mmol, 1.20 eq) and DMF (15 mL) were added to a microwave vial and microwaved at 200° C. for 30 minutes. The reaction was filtered and concentrated on silica gel (5 g). The silica gel was loaded on top a fresh bed of silica gel and washed with 50% ethyl acetate/hexane. The solvents were removed in vacuo and the crude mixture was purified by flash chromatography on silica gel afforded 735 mg (43%) of the title compound as a golden oil: 1H NMR (400 MHz, DMSO-d6) δ 9.07 (s, 1H), 8.73 (s, 2H), 7.58 (t, J=1.7 Hz, 1H), 7.43 (t, J=1.9 Hz, 1H), 7.35 (t, J=2.0 Hz, 1H); ES-MS [M+1]+: 285.0.

Provenance & Evidence