Benzoyl chloride, 3-chloro- → HCID 58337443, compound

Participants

Reaction Steps

Compound 9 (29 mg, 0.13 mmol, 1.0 eq) was dissolved in CH2Cl2 (1.2 mL) and DMAP (32 mg, 0.26 mmol, 2.0 eq) was added and the reaction stirred for 5 min. 3-Chlorobenzoyl chloride (23 mg, 0.13 mmol, 1.0 eq) was added and the reaction was stirred until determination of completion by LCMS. The reaction was diluted with CH2Cl2, washed with water (1×), dried (MgSO4), filtered and concentrated in vacuo. Purification by flash chromatography on silica gel afforded 2.9 mg (6%) of the title compound as a white solid: 1H NMR (400 MHz, DMSO-d6) δ 10.54 (s, 1H), 9.07 (s, 1H), 8.75 (s, 2H), 7.96 (t, J=1.7 Hz, 1H), 7.87 (d, J=7.8 Hz, 1H), 7.81 (t, J=1.7 Hz, 1H), 7.68-7.66 (m, 1H), 7.56 (t, J=7.9 Hz, 1H), 7.46 (t, J=2.0 Hz, 1H), 7.05 (t, J=2.0 Hz, 1H); ES-MS [M+1]+: 360.1.

Provenance & Evidence