HCID 68955567, compound → HCID 16041650, compound

Participants

Reaction Steps

A product obtained in Example 16 (0.08 g, 0.16 mmol) was hydrogenated in the present of Raney-Ni. The desired product was obtained following the synthetic procedure described in Example 1, 4 or 7. The crude product was purified by silica chromatography (ethyl acetate/petroleum ether) to give pale yellow powder (0.013 g, 19.9%). mp 184° C. 1HNMR (DMSO-d6) δ: 2.28˜2.56 (3H, m, CH2), 2.71˜2.88 (2H, m, CH2), 3.04˜3.31 (3H, m, CH2 and N—CH), 3.61 (2H, t, OCH2), 3.73 (3H, s, Ar—OCH3), 3.78 (3H, s, Ar—OCH3), 3.94 (2H, m, OCH2), 4.18 (1H, d, CH2), 6.64 (1H, s, ArH), 6.72 (1H, s, ArH), 7.03 (1H, s, ArH).

Provenance & Evidence