HCID 68953670, compound → HCID 16041651, compound

Participants

Reaction Steps

A product obtained in Example 20 (0.09 g, 0.17 mmol) was hydrogenated in the present of Raney-Ni. The desired product was obtained following the synthetic procedure described in Example 1, 4 or 7. The crude product was recrystallized with CH2Cl2/hexane to give pink solid (0.044 g, 59.0%). mp 169˜170° C. 1HNMR (CDCl3) δ: 1.39 (3H, t, CH3), 2.59˜2.68 (3H, m, CH2), 3.10˜3.16 (2H, m, CH2), 3.33˜3.56 (3H, m, CH2 and N—CH), 3.82 (3H, s, Ar—OCH3), 3.88 (3H, s, Ar—OCH3), 4.08 (1H, d, CH2), 4.32 (2H, q, CH2), 5.52 (1H, brs, Ar—OH), 6.60 (1H, s, ArH), 6.87 (1H, s, ArH), 6.91 (1H, s, ArH). MS (EI) m/z: 432 (M−1), 344 (base), 183, 176, 91.

Provenance & Evidence