HCID 86673913, compound → HCID 71008555, compound

Participants

Reaction Conditions

Reaction Steps

To N-But-3-enyl-N-(4-trifluoromethoxy-phenyl)-acrylamide (0.8 g, 2.6 mmol) in DCM (20 mL) was added Grubbs catalyst (0.12 g, 0.14 mmol) and the mixture was heated to 45° C. overnight. The solvent was removed by reduced pressure and the residue was purified by silica gel column chromatography (eluting with petroleum ether/ethyl acetate=10/1) to afford the title compound (0.6 g, 82%). 1H NMR (300 MHz, CDCl3): δ 7.35-7.21 (m, 4H), 6.74-6.71 (m, 1H), 6.07-6.05 (m, 1H), 3.87-3.82 (m, 2H), 2.57-2.51 (m, 2H); LC-MS: [M+1]+ 258.1.

Provenance & Evidence