HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 6-[4-(2-Dimethylaminoethoxy)phenyl]-2-p-tolyl-5,6-dihydro-4H-thieno[2,3-c]pyridin-7-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-[2-(Dimethylamino)ethoxy]aniline | HCID 6484655 | — |
| Reactant | 3-Methyl-5-p-tolylthiophene-2-carboxylic acid | HCID 66879104 | — |
| Product | 6-[4-(2-Dimethylaminoethoxy)phenyl]-2-p-tolyl-5,6-dihydro-4H-thieno[2,3-c]pyridin-7-one | HCID 57626110 | — |
Reaction Steps
Firstly 3-methyl-5-p-tolylthiophene-2-carboxylic acid was reacted with paraformaldehyde by method C1, and then the product was treated with thionyl chloride by method B. The resulting dichloride was finally reacted with 4-(2-dimethylaminoethoxy)phenylamine by method A. The product with the molecular weight of 406.55 (C24H26N2O2S) was obtained in this way; MS (ESI): 407 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08501771B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-630192cbed86462397c446906a600e0d |
| Source note | uspto-grants-2013_08 |