HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1887542Generated: October 27, 2026
Water → 6-[(R)-1-(Tetrahydrofuran-2-yl)methoxy]isochromen-1-one
https://huagongshe.com/reaction/1887542
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | (Tetrahydrofuran-2-yl)methyl methanesulfonate | HCID 266119 | — |
| Reactant | 6-Hydroxyisochromen-1-one | HCID 66879699 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-[(R)-1-(Tetrahydrofuran-2-yl)methoxy]isochromen-1-one | HCID 66878936 | — |
Reaction Steps
Methanesulfonic acid tetrahydrofuran-2-ylmethyl ester (2.7 g) and cesium carbonate (12 g) were added to a solution of 6-hydroxyisochromen-1-one (2 g) in DMF (50 mL) and the mixture was stirred at 80° C. for 7 h. After addition of water, the mixture was extracted with dichloromethane, dried over magnesium sulfate and concentrated. The product with the molecular weight of 246.27 (C14H14O4) was obtained in this way; MS (ESI): 247 (M+H+). 6-[(R)-1-(Tetrahydrofuran-2-yl)methoxy]isochromen-1-one was synthesized analogously.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08501771B2 |
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| Source dataset | uspto-grants-2013_08 |
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| ORD ID | ord-79b0d73904a642d8a184a9388cbecde8 |
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| Source note | uspto-grants-2013_08 |
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