反应详情

A solution of boron tribromide (1M in dichloromethane, 130 mL) was added to a solution of 6-methoxyisochromen-1-one (9.3 g) in dichloromethane (300 mL) at 0° C., and the mixture was stirred at room temperature for 16 h. After addition of sodium carbonate solution, the mixture was washed with ethyl acetate, and the aqueous phase was acidified with 2N HCl, extracted with ethyl acetate, dried over magnesium sulfate and concentrated. The residue was chromatographed on silica gel. The product with the molecular weight of 162.15 (C9H6O3) was obtained in this way; MS (ESI): 163 (M+H+).

1. washthe mixture was washed with ethyl acetate
2. extractionextracted with ethyl acetate
3. dry with materialdried over magnesium sulfate
4. concentrationconcentrated
5. customThe residue was chromatographed on silica gel
6. customThe product with the molecular weight of 162.15 (C9H6O3) was obtained in this way