HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 3-(2,5-dimethyl-1H-pyrrol-1-yl)-1-methyl-1H-pyrazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2,5-Hexanedione | HCID 8035 | — |
| Reactant | 1-Methyl-3-aminopyrazole | HCID 137254 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 3-(2,5-dimethyl-1H-pyrrol-1-yl)-1-methyl-1H-pyrazole | HCID 13248995 | — |
Reaction Steps
To a solution of 1-methyl-1H-pyrazol-3-amine (9.5 g, 98 mmol) and acetonylacetone (11.2 g, 98 mmol) in toluene (150 mL), AcOH (1.5 mL) is added, heated to reflux with a water separator until the formation of water ceased. Concentrated to dry. The residue is purified by flash column to give product. MS (ESI) m/z 176.3 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08501756B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-97049468f6e14b8eb1dcf949002eff6d |
| Source note | uspto-grants-2013_08 |