HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → Trifluoroacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Binap, (A+-)- | HCID 634876 | — |
| Reactant | 2-Methoxy-4-(4-methylpiperazin-1-yl)aniline | HCID 20136253 | — |
| Reactant | 2-[2-Chloro-5-(trifluoromethyl)pyridin-4-ylamino]-N-methylbenzamide | HCID 56655328 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Trifluoroacetic acid | HCID 6422 | — |
| Product | 2-(2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-5-(trifluoromethyl)pyridin-4-ylamino)-N-methylbenzamide | HCID 25074080 | — |
Reaction Steps
Method C was applied to a mixture of 2-(2-chloro-5-(trifluoromethyl)pyridin-4-ylamino)-N-methylbenzamide (30 mg, 0.091 mmol), 2-methoxy-4-(4-methylpiperazin-1-yl)aniline (40 mg, 0.18 mmol), Pd2(dba)3 (11 mg, 0.012 mmol), rac-BINAP (12 mg, 0.019 mmol) and cesium carbonate (75 mg, 0.23 mmol) in dioxane (3 ml). The bis-TFA salt of the title compound was obtained as a pale yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08501763B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-984228858774457e951f5c25e53c0ad3 |
| Source note | uspto-grants-2013_08 |