HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1887678Generated: November 1, 2026
2-Chloro-4-iodo-5-(trifluoromethyl)pyridine → 2-Chloro-5-(trifluoromethyl)-4-pyridinamine
https://huagongshe.com/reaction/1887678
Participants
| Role | Name | HCID | Charge |
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| Reactant | 2-Chloro-4-iodo-5-(trifluoromethyl)pyridine | HCID 2773791 | — |
| Reactant | Ammonia methanol | HCID 21705897 | — |
| Product | 2-Chloro-5-(trifluoromethyl)-4-pyridinamine | HCID 71306156 | — |
Reaction Steps
2-chloro-4-iodo-5-(trifluoromethyl)pyridine was dissolved in 7 M Ammonia/Methanol. It was heated in a Biotage Initiator microwave synthesizer at 130° C. for 1 h. A mixture of the 2- and 4-substituted products was obtained. The solvent was removed and the residue was purified by silica gel chromatography (DCM/MeOH) gradient. The pure title compound was isolated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08501763B2 |
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| Source dataset | uspto-grants-2013_08 |
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| ORD ID | ord-9b41f0139f354fb48a2eae08892cfa9a |
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| Source note | uspto-grants-2013_08 |
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