HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → Methyl 4-(2-chloro-5-(trifluoromethyl)pyridin-4-ylamino)-2-(methylthio)thiazole-5-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Methyl 4-amino-2-(methylsulfanyl)-1,3-thiazole-5-carboxylate | HCID 609212 | — |
| Reactant | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| Reactant | 2-Chloro-4-iodo-5-(trifluoromethyl)pyridine | HCID 2773791 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Methyl 4-(2-chloro-5-(trifluoromethyl)pyridin-4-ylamino)-2-(methylthio)thiazole-5-carboxylate | HCID 58155161 | — |
Reaction Steps
Method A was applied to a mixture of 2-chloro-4-iodo-5-(trifluoromethyl)pyridine (156 mg, 0.51 mmol) and methyl 4-amino-2-(methylthio)thiazole-5-carboxylate (86 mg, 0.42 mmol), Pd2(dba)3 (26 mg, 0.028 mmol), xantphos (21 mg, 0.036 mmol) and cesium carbonate (270 mg, 0.83 mmol) in dioxane (4.5 ml).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08501763B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-c3afb3c991c04f78a727fb1ac0abdd2b |
| Source note | uspto-grants-2013_08 |