Cesium carbonate → Trifluoroacetic acid

Participants

Role	Name	HCID	Charge
Reactant	Cesium carbonate	HCID 10796	—
Reactant	1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine)	HCID 636044	—
Reactant	2-Methoxy-4-(4-methylpiperazin-1-yl)aniline	HCID 20136253	—
Reactant	2-Chloro-N-(2-(pyrimidin-2-yl)phenyl)-5-(trifluoromethyl)pyridin-4-amine	HCID 58154965	—
Catalyst	Bis(dibenzylideneacetone)palladium	HCID 9811564	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	Trifluoroacetic acid	HCID 6422	—
Product	N2-(2-Methoxy-4-(4-methylpiperazin-1-yl)phenyl)-N4-(2-(pyrimidin-2-yl)phenyl)-5-(trifluoromethyl)pyridine-2,4-diamine	HCID 58154991	—

Reaction Steps

Method C was applied to the mixture of 2-chloro-N-(2-(pyrimidin-2-yl)phenyl)-5-(trifluoromethyl)pyridin-4-amine (30 mg, 0.086 mmol), 2-methoxy-4-(4-methylpiperazin-1-yl)aniline (31 mg, 0.14 mmol), Pd2(dba)3 (11 mg, 0.012 mmol), xantphos (11 mg, 0.019 mmol) and cesium carbonate (590 mg, 0.18 mmol) in dioxane (3 ml). The bis-TFA salt of the title compound was obtained as a yellow solid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08501763B2
Source dataset	uspto-grants-2013_08
ORD ID	ord-f7016e5a018045a7a023db887145d3a3
Source note	uspto-grants-2013_08