4,5-difluoro-N-methyl-2-nitrobenzamide → HCID 57974170, compound

HRID 1887699Notes

Reaction equation

HRID 1887699 reaction equation
[F:1][C:2]1[C:11]([F:12])=[CH:10][C:5]([C:6]([NH:8][CH3:9])=[O:7])=[C:4]([N+:13]([O-])=O)[CH:3]=1.[H][H]>CO.[Pd]>[NH2:13][C:4]1[CH:3]=[C:2]([F:1])[C:11]([F:12])=[CH:10][C:5]=1[C:6]([NH:8][CH3:9])=[O:7]

Participants

5

Reactant 2

HCID 619939344,5-difluoro-N-methyl-2-nitrobenzamideHCID 178418361HCID 178418361, compound2×

Product 1

HCID 57974170HCID 57974170, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To 4,5-difluoro-N-methyl-2-nitrobenzamide (1.33 g, 6.15 mmol) in methanol (50 mL) was added Pd/C (10% Pd in carbon, 200 mg, 15 wt %) under argon. A hydrogen balloon was used as hydrogen source. The reaction was stirred at room temperature overnight. The mixture was filtered through celite and the celite pad was washed several times. The solvent was removed the crude was purified by silica gel chromatography to obtain the desired product (quantitative yield).

Workup

  1. filtrationThe mixture was filtered through celite
  2. washthe celite pad was washed several times
  3. customThe solvent was removed the crude
  4. customwas purified by silica gel chromatography

Sources & evidence

ORD record
ord-c3b9679742b84d70a16bb2de293a8d62
Source dataset
uspto-grants-2013_08
Patent number
US08501763B2

Reaction notes

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