HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1887715Generated: November 2, 2026
Triethylamine → 1-Methyl-5-nitroindolin-2-one
https://huagongshe.com/reaction/1887715
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-(Di-tert-butylphosphino)biphenyl | HCID 2734215 | — |
| Reactant | 2-Chloro-N-methyl-N-(4-nitro-phenyl)-acetamide | HCID 11436129 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1-Methyl-5-nitroindolin-2-one | HCID 2727961 | — |
Reaction Steps
The mixture of 2-Chloro-N-methyl-N-(4-nitrophenyl)acetamide (100 mg, 0.44 mmol), Pd2(dba)3 (20 mg, 0.022 mmol), 2-(di-tert-butylphosphino)biphenyl (13 mg, 0.044 mmol) and triethylamine (91 μl, 0.66 mmol) in toluene was heated at 80° C. for 3 h. The reaction was 78% complete by NMR.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08501763B2 |
|---|
| Source dataset | uspto-grants-2013_08 |
|---|
| ORD ID | ord-534ba9b39bb1409e9030f1b03df5d556 |
|---|
| Source note | uspto-grants-2013_08 |
|---|
