反应详情

To a suspension of 1-methyl-5-nitroindolin-2-one (92 mg, 0.48 mmol) in 20 mL MeOH, was Pd(C) (9.2 mg, 10 weight %) added. The round bottom flask was capped with a rubber septum and put under a hydrogen atmosphere. After 18 h the hydrogen gas was evacuated by introducing argon to the round bottom flask. The reaction mixture was filtered through celite. The celite was washed with EtOAc (2×30 ml). The volatiles were evaporated to afford the title compound in quantitative yield.

1. additionadded
2. customThe round bottom flask was capped with a rubber septum
3. customAfter 18 h the hydrogen gas was evacuated
4. additionby introducing argon to the round bottom flask
5. filtrationThe reaction mixture was filtered through celite
6. washThe celite was washed with EtOAc (2×30 ml)
7. customThe volatiles were evaporated