HuagongsheHuagongshe Chemistry Print Report · For research reference only
Boc-D-Trp(Me)-OH → HCID 59620348, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Boc-D-Trp(Me)-OH | HCID 13821420 | — |
| Reactant | 3-amino-8-(2-oxopyrrolidin-1-yl)-1-(thiophen-3-ylmethyl)-3,4-dihydroquinolin-2(1H)-one | HCID 59620330 | — |
| Product | HCID 59620348 | HCID 59620348 | 110.8% |
Reaction Steps
The procedure of Example 14(a) was repeated, except that (−)-3-amino-8-(2-oxopyrrolidin-1-yl)-1-(thiophen-3-ylmethyl)-3,4-dihydroquinolin-2(1H)-one (268 mg) and (R)-2-(tert-butoxycarbonylamino)-3-(1-methyl-1H-indol-3-yl)propanoic acid (284 mg) synthesized in Referential Example 1(a) were used, whereby the title compound (558 mg) was yielded.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08501772B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-b5c1e3ce470e4869a81e044dba1fe32b |
| Source note | uspto-grants-2013_08 |