Azobisisobutyronitrile → 3-bromomethyl-7-chloro-2-oxazol-2-yl-1-phenyl-1H-quinolin-4-one

Participants

Reaction Steps

In a 250 mL round bottom flask, 7-chloro-3-methyl-2-oxazol-2-yl-1-phenyl-1H-quinolin-4-one (0.50 g, 1.48 mmol), N-bromosuccinimide (291 mg, 1.63 mmol) and 2,2′-azobisisobutyronitrile (AIBN, 36.6 mg, 0.223 mmol) were combined with carbon tetrachloride (20 mL). The mixture was heated to reflux for 2 hr. The reaction was cooled to room temperature and solids were filtered off. The mother liquor was concentrated and purified by flash chromatography using 3:2 hexane-ethyl acetate to afford 3-bromomethyl-7-chloro-2-oxazol-2-yl-1-phenyl-1H-quinolin-4-one (300 mg, 49% yield) as a white solid.

Provenance & Evidence