HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1887788Generated: November 2, 2026
Trifluoroacetic acid → 3-aminomethyl-2-oxazol-2-yl-1-phenyl-1H-[1,8]naphthyridin-4-one trifluoroacetate salt
https://huagongshe.com/reaction/1887788
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 3-aminomethyl-2-oxazol-2-yl-1-phenyl-1H-[1, 8]naphthyridin-4-one bis(tert-butyl carbamate) | HCID 86675763 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-aminomethyl-2-oxazol-2-yl-1-phenyl-1H-[1,8]naphthyridin-4-one trifluoroacetate salt | HCID 71209030 | — |
Reaction Steps
A solution of 3-aminomethyl-2-oxazol-2-yl-1-phenyl-1H-[1,8]naphthyridin-4-one bis(tert-butyl carbamate) (26 mg, 50.1 μmol) in methylene chloride (167 μL) at 25° C. was treated with TFA (83.6 μL). The reaction was stirred at 25° C. for 4 hr. The reaction was concentrated in vacuo, triturated with diethyl ether and then dried under high vacuum to give 3-aminomethyl-2-oxazol-2-yl-1-phenyl-1H-[1,8]naphthyridin-4-one trifluoroacetate salt. The product was used in subsequent steps without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08501732B2 |
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| Source dataset | uspto-grants-2013_08 |
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| ORD ID | ord-9b35ba403c4040b9b029843a4ff72783 |
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| Source note | uspto-grants-2013_08 |
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