6-Morpholinonicotinic Acid → 6-Morpholin-4-yl-N-(2-oxazol-2-yl-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridin-3-yl-methyl)-nicotinamide

関与物質

反応手順

6-Morpholin-4-yl-N-(2-oxazol-2-yl-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridin-3-yl-methyl)-nicotinamide was prepared starting from intermediate B and 6-morpholin-4-yl-nicotinic acid. 1H NMR (300 MHz, DMSO-d6) δ ppm 8.65-8.67 (m, 2H) 8.48 (d, J=2.90 Hz, 1H) 8.05-8.15 (m, 1H) 7.98 (d, J=0.75 Hz, 1H) 7.85 (dd, J=8.70, 2.90 Hz, 1H) 7.55 (dd, J=8.20, 4.40 Hz, 1H) 7.23-7.45 (m, 5H) 7.18 (d, J=0.75 Hz, 1H) 6.79 (d, J=8.30 Hz, 1H) 4.25 (d, J=4.20 Hz, 2H) 3.62-3.73 (m, 4H) 3.47-3.57 (m, 4H).

情報源と証拠