2-(Morpholin-4-yl)-1,3-thiazole-5-carboxylic acid → HCID 71208330, compound

HRID 1887843Notes

Reaction equation

HRID 1887843 reaction equation
[NH2:1][CH2:2][C:3]1[C:12](=[O:13])[C:11]2[C:6](=[CH:7][C:8]([Cl:14])=[CH:9][CH:10]=2)[N:5]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:4]=1[C:21]([N:23]([CH3:25])[CH3:24])=[O:22].[N:26]1([C:32]2[S:33][C:34]([C:37](O)=[O:38])=[CH:35][N:36]=2)[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1>>[CH3:24][N:23]([CH3:25])[C:21]([C:4]1[N:5]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:6]2[C:11]([C:12](=[O:13])[C:3]=1[CH2:2][NH:1][C:37]([C:34]1[S:33][C:32]([N:26]3[CH2:31][CH2:30][O:29][CH2:28][CH2:27]3)=[N:36][CH:35]=1)=[O:38])=[CH:10][CH:9]=[C:8]([Cl:14])[CH:7]=2)=[O:22]

Participants

3

Reactant 2

HCID 154758352-(Morpholin-4-yl)-1,3-thiazole-5-carboxylic acidHCID 712086753-(aminomethyl)-7-chloro-N,N-dimethyl-4-oxo-1-phenyl-1,4-dihydroquinoline-2-carboxamide

Product 1

HCID 71208330HCID 71208330, compound

Procedure

7-Chloro-3-{[(2-morpholin-4-yl-thiazole-5-carbonyl)-amino]-methyl}-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid dimethylamide was prepared starting from intermediate C and 2-morpholin-4-yl-thiazole-5-carboxylic acid. MS calcd. for C27H26ClN5O4S [(M+H)+] 552.1, obsd. 552.0.

Sources & evidence

ORD record
ord-9103ddb6711845d79cee6bb5f9b98583
Source dataset
uspto-grants-2013_08
Patent number
US08501732B2

Reaction notes

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