4-(Morpholin-4-yl)benzoic acid → 7-Chloro-3-[(4-morpholin-4-yl-benzoylamino)-methyl]-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid dimethylamide

HRID 1887846Notes

Reaction equation

HRID 1887846 reaction equation
[NH2:1][CH2:2][C:3]1[C:12](=[O:13])[C:11]2[C:6](=[CH:7][C:8]([Cl:14])=[CH:9][CH:10]=2)[N:5]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:4]=1[C:21]([N:23]([CH3:25])[CH3:24])=[O:22].[N:26]1([C:32]2[CH:40]=[CH:39][C:35]([C:36](O)=[O:37])=[CH:34][CH:33]=2)[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1>>[CH3:24][N:23]([CH3:25])[C:21]([C:4]1[N:5]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:6]2[C:11]([C:12](=[O:13])[C:3]=1[CH2:2][NH:1][C:36](=[O:37])[C:35]1[CH:34]=[CH:33][C:32]([N:26]3[CH2:31][CH2:30][O:29][CH2:28][CH2:27]3)=[CH:40][CH:39]=1)=[CH:10][CH:9]=[C:8]([Cl:14])[CH:7]=2)=[O:22]

Participants

3

Reactant 2

HCID 3452784-(Morpholin-4-yl)benzoic acidHCID 712086753-(aminomethyl)-7-chloro-N,N-dimethyl-4-oxo-1-phenyl-1,4-dihydroquinoline-2-carboxamide

Product 1

HCID 712092307-Chloro-3-[(4-morpholin-4-yl-benzoylamino)-methyl]-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid dimethylamide

Procedure

7-Chloro-3-[(4-morpholin-4-yl-benzoylamino)-methyl]-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid dimethylamide was prepared starting from intermediate C and 4-morpholin-4-yl-benzoic acid. MS calcd. for C30H29ClN4O4 [(M+H)+] 545.2, obsd. 545.2.

Sources & evidence

ORD record
ord-7e9b08ccf6bf472a826521559ae47df0
Source dataset
uspto-grants-2013_08
Patent number
US08501732B2

Reaction notes

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