4-Fluorobenzoic Acid → 7-Chloro-3-[(4-fluoro-benzoylamino)-methyl]-4-oxo-1-phenyl-1,4-di-hydro-quinoline-2-carboxylic acid dimethylamide

HRID 1887848Notes

Reaction equation

HRID 1887848 reaction equation
[NH2:1][CH2:2][C:3]1[C:12](=[O:13])[C:11]2[C:6](=[CH:7][C:8]([Cl:14])=[CH:9][CH:10]=2)[N:5]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:4]=1[C:21]([N:23]([CH3:25])[CH3:24])=[O:22].[F:26][C:27]1[CH:35]=[CH:34][C:30]([C:31](O)=[O:32])=[CH:29][CH:28]=1>>[CH3:24][N:23]([CH3:25])[C:21]([C:4]1[N:5]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:6]2[C:11]([C:12](=[O:13])[C:3]=1[CH2:2][NH:1][C:31](=[O:32])[C:30]1[CH:34]=[CH:35][C:27]([F:26])=[CH:28][CH:29]=1)=[CH:10][CH:9]=[C:8]([Cl:14])[CH:7]=2)=[O:22]

Participants

3

Reactant 2

HCID 99734-Fluorobenzoic AcidHCID 712086753-(aminomethyl)-7-chloro-N,N-dimethyl-4-oxo-1-phenyl-1,4-dihydroquinoline-2-carboxamide

Product 1

HCID 712085797-Chloro-3-[(4-fluoro-benzoylamino)-methyl]-4-oxo-1-phenyl-1,4-di-hydro-quinoline-2-carboxylic acid dimethylamide

Procedure

7-Chloro-3-[(4-fluoro-benzoylamino)-methyl]-4-oxo-1-phenyl-1,4-di-hydro-quinoline-2-carboxylic acid dimethylamide was prepared starting from intermediate C and 4-fluoro-benzoic acid. MS calcd. for C26H21ClFN3O3 [(M+H)+] 478.1, obsd. 477.9.

Sources & evidence

ORD record
ord-ccd145261aee4640bc4b0465226050f1
Source dataset
uspto-grants-2013_08
Patent number
US08501732B2

Reaction notes

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