1,4-Benzodioxane-6-carboxylic Acid → HCID 71208243, compound

HRID 1887849Notes

Reaction equation

HRID 1887849 reaction equation
[NH2:1][CH2:2][C:3]1[C:12](=[O:13])[C:11]2[C:6](=[CH:7][C:8]([Cl:14])=[CH:9][CH:10]=2)[N:5]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:4]=1[C:21]([N:23]([CH3:25])[CH3:24])=[O:22].[O:26]1[C:31]2[CH:32]=[CH:33][C:34]([C:36](O)=[O:37])=[CH:35][C:30]=2[O:29][CH2:28][CH2:27]1>>[CH3:24][N:23]([CH3:25])[C:21]([C:4]1[N:5]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:6]2[C:11]([C:12](=[O:13])[C:3]=1[CH2:2][NH:1][C:36]([C:34]1[CH:33]=[CH:32][C:31]3[O:26][CH2:27][CH2:28][O:29][C:30]=3[CH:35]=1)=[O:37])=[CH:10][CH:9]=[C:8]([Cl:14])[CH:7]=2)=[O:22]

Participants

3

Reactant 2

HCID 27588331,4-Benzodioxane-6-carboxylic AcidHCID 712086753-(aminomethyl)-7-chloro-N,N-dimethyl-4-oxo-1-phenyl-1,4-dihydroquinoline-2-carboxamide

Product 1

HCID 71208243HCID 71208243, compound

Procedure

7-Chloro-3-{[(2,3-dihydro-benzo[1,4]dioxine-6-carbonyl)-amino]-methyl}-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid dimethylamide was prepared starting from intermediate C and 2,3-dihydrobenzo-[1,4]dioxine-6-carboxylic acid. MS calcd. for C28H24ClN3O5 [(M+H)+] 518, obsd. 518.

Sources & evidence

ORD record
ord-f95929ce051c416fad71c05b5d1da006
Source dataset
uspto-grants-2013_08
Patent number
US08501732B2

Reaction notes

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