1,3-Benzothiazole-5-carboxylic acid → Benzothiazole-5-carboxylic acid (7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-amide

HRID 1887867Notes

Reaction equation

HRID 1887867 reaction equation
[NH2:1][CH2:2][C:3]1[C:12](=[O:13])[C:11]2[C:6](=[CH:7][C:8]([Cl:14])=[CH:9][CH:10]=2)[N:5]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:4]=1.[S:21]1[C:25]2[CH:26]=[CH:27][C:28]([C:30](O)=[O:31])=[CH:29][C:24]=2[N:23]=[CH:22]1>>[Cl:14][C:8]1[CH:7]=[C:6]2[C:11]([C:12](=[O:13])[C:3]([CH2:2][NH:1][C:30]([C:28]3[CH:27]=[CH:26][C:25]4[S:21][CH:22]=[N:23][C:24]=4[CH:29]=3)=[O:31])=[CH:4][N:5]2[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 27354601,3-Benzothiazole-5-carboxylic acidHCID 712083983-(aminomethyl)-7-chloro-1-phenylquinolin-4(1H)-one

Product 1

HCID 71217346Benzothiazole-5-carboxylic acid (7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-amide

Procedure

Benzothiazole-5-carboxylic acid (7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-amide was prepared starting from intermediate D and benzothiazole-5-carboxylic acid. MS calcd. for C24H17ClN3O2S [(M+H)+] 446.1, obsd. 445.9.

Sources & evidence

ORD record
ord-01e9e6496e1941fd8f12621a1a1e9d40
Source dataset
uspto-grants-2013_08
Patent number
US08501732B2

Reaction notes

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