1H-indole-6-carboxylic acid → HCID 71229277, compound

HRID 1887871Notes

Reaction equation

HRID 1887871 reaction equation
[NH2:1][CH2:2][C:3]1[C:12](=[O:13])[C:11]2[C:6](=[CH:7][C:8]([Cl:14])=[CH:9][CH:10]=2)[N:5]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:4]=1.[NH:21]1[C:29]2[C:24](=[CH:25][CH:26]=[C:27]([C:30](O)=[O:31])[CH:28]=2)[CH:23]=[CH:22]1>>[Cl:14][C:8]1[CH:7]=[C:6]2[C:11]([C:12](=[O:13])[C:3]([CH2:2][NH:1][C:30]([C:27]3[CH:28]=[C:29]4[C:24]([CH:23]=[CH:22][NH:21]4)=[CH:25][CH:26]=3)=[O:31])=[CH:4][N:5]2[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 5952301H-indole-6-carboxylic acidHCID 712083983-(aminomethyl)-7-chloro-1-phenylquinolin-4(1H)-one

Product 1

HCID 71229277HCID 71229277, compound

Procedure

1H-Indole-6-carboxylic acid (7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-amide was prepared starting from intermediate D and 1H-Indole-6-carboxylic acid. MS calcd. for C25H19ClN3O2 [(M+H)+] 428.1, obsd. 427.9.

Sources & evidence

ORD record
ord-e73914e0706b419a95e46d1652db1a6f
Source dataset
uspto-grants-2013_08
Patent number
US08501732B2

Reaction notes

Loading…