3-(aminomethyl)-7-chloro-1-phenylquinolin-4(1H)-one → HCID 71217349, compound

HRID 1887873Notes

Reaction equation

HRID 1887873 reaction equation
[NH2:1][CH2:2][C:3]1[C:12](=[O:13])[C:11]2[C:6](=[CH:7][C:8]([Cl:14])=[CH:9][CH:10]=2)[N:5]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:4]=1.[CH3:21][O:22][C:23]1[CH:39]=[CH:38][CH:37]=[CH:36][C:24]=1[CH2:25][N:26]1[CH:31]=[CH:30][C:29]([C:32](O)=[O:33])=[CH:28][C:27]1=[O:35]>>[Cl:14][C:8]1[CH:7]=[C:6]2[C:11]([C:12](=[O:13])[C:3]([CH2:2][NH:1][C:32]([C:29]3[CH:30]=[CH:31][N:26]([CH2:25][C:24]4[CH:36]=[CH:37][CH:38]=[CH:39][C:23]=4[O:22][CH3:21])[C:27](=[O:35])[CH:28]=3)=[O:33])=[CH:4][N:5]2[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 712083983-(aminomethyl)-7-chloro-1-phenylquinolin-4(1H)-oneHCID 71208577HCID 71208577, compound

Product 1

HCID 71217349HCID 71217349, compound

Procedure

1-(2-Methoxy-benzyl)-2-oxo-1,2-dihydro-pyridine-4-carboxylic acid (7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-amide was prepared starting from intermediate D and 1-(2-methoxy-benzyl)-2-oxo-1,2-dihydro-pyridine-4-carboxylic acid. MS calcd. for C30H25ClN3O4 [(M+H)+] 526.2, obsd. 526.0.

Sources & evidence

ORD record
ord-36deeb358dd348139b593a529b956ad5
Source dataset
uspto-grants-2013_08
Patent number
US08501732B2

Reaction notes

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