4-Carbamoylbenzoic acid → HCID 71208690, compound

HRID 1887874Notes

Reaction equation

HRID 1887874 reaction equation
[NH2:1][CH2:2][C:3]1[C:12](=[O:13])[C:11]2[C:6](=[CH:7][C:8]([Cl:14])=[CH:9][CH:10]=2)[N:5]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:4]=1.[NH2:21][C:22]([C:24]1[CH:32]=[CH:31][C:27]([C:28](O)=[O:29])=[CH:26][CH:25]=1)=[O:23]>>[Cl:14][C:8]1[CH:7]=[C:6]2[C:11]([C:12](=[O:13])[C:3]([CH2:2][NH:1][C:28](=[O:29])[C:27]3[CH:31]=[CH:32][C:24]([C:22]([NH2:21])=[O:23])=[CH:25][CH:26]=3)=[CH:4][N:5]2[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 5060574-Carbamoylbenzoic acidHCID 712083983-(aminomethyl)-7-chloro-1-phenylquinolin-4(1H)-one

Product 1

HCID 71208690HCID 71208690, compound

Procedure

N-(7-Chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-terephthalamide was prepared starting from intermediate D and 4-(aminocarbonyl)benzoic acid. MS calcd. for C24H18ClN3O3 [(M+H)+] 431.9, obsd. 432.0.

Sources & evidence

ORD record
ord-8622cbacec034d34adaeabeb3d9ea86a
Source dataset
uspto-grants-2013_08
Patent number
US08501732B2

Reaction notes

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