1-((Tert-butoxy)carbonyl)pyrrolidine-3-carboxylic acid → HCID 71208613, compound

HRID 1887875Notes

Reaction equation

HRID 1887875 reaction equation
[NH2:1][CH2:2][C:3]1[C:12](=[O:13])[C:11]2[C:6](=[CH:7][C:8]([Cl:14])=[CH:9][CH:10]=2)[N:5]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:4]=1.[C:21]([O:25][C:26]([N:28]1[CH2:32][CH2:31][CH:30]([C:33](O)=[O:34])[CH2:29]1)=[O:27])([CH3:24])([CH3:23])[CH3:22]>>[C:21]([O:25][C:26]([N:28]1[CH2:32][CH2:31][CH:30]([C:33](=[O:34])[NH:1][CH2:2][C:3]2[C:12](=[O:13])[C:11]3[C:6](=[CH:7][C:8]([Cl:14])=[CH:9][CH:10]=3)[N:5]([C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:4]=2)[CH2:29]1)=[O:27])([CH3:24])([CH3:23])[CH3:22]

Participants

3

Reactant 2

HCID 27605291-((Tert-butoxy)carbonyl)pyrrolidine-3-carboxylic acidHCID 712083983-(aminomethyl)-7-chloro-1-phenylquinolin-4(1H)-one

Product 1

HCID 71208613HCID 71208613, compound

Procedure

3-[(7-Chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-carbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester was prepared starting from intermediate D and 1-(tert-butoxycarbonyl)-pyrrolidine-3-carboxylic acid. MS calcd. for C26H29ClN3O4 [(M+H)+] 481.3, obsd. 482.0.

Sources & evidence

ORD record
ord-87f7566af5c045369534c0300da7b39d
Source dataset
uspto-grants-2013_08
Patent number
US08501732B2

Reaction notes

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