HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,3-Difluorobenzoyl chloride → N-(7-Chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-2,3-difluoro-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,3-Difluorobenzoyl chloride | HCID 519549 | — |
| Reactant | 3-(aminomethyl)-7-chloro-1-phenylquinolin-4(1H)-one | HCID 71208398 | — |
| Product | N-(7-Chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-2,3-difluoro-benzamide | HCID 71208645 | — |
Reaction Steps
N-(7-Chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-2,3-difluoro-benzamide was prepared starting from intermediate D and 2,3-difluoro-benzoyl chloride. 1H NMR (400 MHz, DMSO-d6) δ ppm 8.75 (s, 1H) 8.28 (d, J=8.66 Hz, 1H) 8.00 (s, 1H) 7.15-7.80 (m, 9H) 6.92 (d, J=1.81 Hz, 1H) 0.39 (d, J=5.64 Hz, 2H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08501732B2 |
| Source dataset | uspto-grants-2013_08 |
| ORD ID | ord-cde2cbe80f5c4584b3318839aeadd272 |
| Source note | uspto-grants-2013_08 |