1-Piperazinecarboxamide → HCID 71208692, compound

HRID 1887892Notes

Reaction equation

Cl[C:2]1[CH:29]=[CH:28][C:5]([C:6]([NH:8][CH2:9][C:10]2[C:19](=[O:20])[C:18]3[C:13](=[CH:14][C:15]([Cl:21])=[CH:16][CH:17]=3)[N:12]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH:11]=2)=[O:7])=[CH:4][N:3]=1.[N:30]1([C:36]([NH2:38])=[O:37])[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]1>>[Cl:21][C:15]1[CH:14]=[C:13]2[C:18]([C:19](=[O:20])[C:10]([CH2:9][NH:8][C:6]([C:5]3[CH:28]=[CH:29][C:2]([N:33]4[CH2:34][CH2:35][N:30]([C:36]([NH2:38])=[O:37])[CH2:31][CH2:32]4)=[N:3][CH:4]=3)=[O:7])=[CH:11][N:12]2[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)=[CH:17][CH:16]=1

Participants

Reactant 2

HCID 2581921-Piperazinecarboxamide

HCID 714870636-chloro-N-((7-chloro-4-oxo-1-phenyl-1,4-dihydroquinolin-3-yl)methyl)nicotinamide

Product 1

HCID 71208692HCID 71208692, compound

Procedure

4-{5-[(7-Chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-carbamoyl]-pyridin-2-yl}-piperazine-1-carboxylic acid amide was prepared starting from intermediate E and piperazine-1-carboxylic acid amide. MS calcd. for C27H25ClN6O3 [(M+H)+] 517.2, obsd. 517.0.

Sources & evidence

ORD record: ord-9bf9b8b69c81448d8407812c382aa7a5
Source dataset: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08501732B2

Reaction notes

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