Thiomorpholine 1,1-dioxide → HCID 71208516, compound

HRID 1887899Notes

Reaction equation

HRID 1887899 reaction equation
Cl[C:2]1[CH:29]=[CH:28][C:5]([C:6]([NH:8][CH2:9][C:10]2[C:19](=[O:20])[C:18]3[C:13](=[CH:14][C:15]([Cl:21])=[CH:16][CH:17]=3)[N:12]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH:11]=2)=[O:7])=[CH:4][N:3]=1.[NH:30]1[CH2:35][CH2:34][S:33](=[O:37])(=[O:36])[CH2:32][CH2:31]1>>[Cl:21][C:15]1[CH:14]=[C:13]2[C:18]([C:19](=[O:20])[C:10]([CH2:9][NH:8][C:6](=[O:7])[C:5]3[CH:28]=[CH:29][C:2]([N:30]4[CH2:35][CH2:34][S:33](=[O:37])(=[O:36])[CH2:32][CH2:31]4)=[N:3][CH:4]=3)=[CH:11][N:12]2[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 6484228Thiomorpholine 1,1-dioxideHCID 714870636-chloro-N-((7-chloro-4-oxo-1-phenyl-1,4-dihydroquinolin-3-yl)methyl)nicotinamide

Product 1

HCID 71208516HCID 71208516, compound

Procedure

N-(7-Chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-6-(1,1-dioxo-thiomorph-olin-4-yl)-nicotinamide was prepared starting from intermediate E and thiomorpholine-1,1-dioxide. MS calcd. for C26H23ClN4O4S [(M+H)+] 523.1, obsd. 523.0.

Sources & evidence

ORD record
ord-e251cc3237d14ae78e32fab07fbada3b
Source dataset
uspto-grants-2013_08
Patent number
US08501732B2

Reaction notes

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