2-Amino-5-chlorobenzophenone → N-(2-benzoyl-4-chloro-phenyl)-4-pyrazol-1-yl-benzenesulfonamide

HRID 18879Notes

Reaction equation

HRID 18879 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:10].[N:17]1([C:22]2[CH:27]=[CH:26][C:25]([S:28](Cl)(=[O:30])=[O:29])=[CH:24][CH:23]=2)[CH:21]=[CH:20][CH:19]=[N:18]1>>[C:9]([C:3]1[CH:4]=[C:5]([Cl:8])[CH:6]=[CH:7][C:2]=1[NH:1][S:28]([C:25]1[CH:24]=[CH:23][C:22]([N:17]2[CH:21]=[CH:20][CH:19]=[N:18]2)=[CH:27][CH:26]=1)(=[O:29])=[O:30])(=[O:10])[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 128702-Amino-5-chlorobenzophenoneHCID 27764754-(1H-pyrazol-1-yl)benzene-1-sulfonyl chloride

Product 1

HCID 11487442N-(2-benzoyl-4-chloro-phenyl)-4-pyrazol-1-yl-benzenesulfonamide

Procedure

The title compound was prepared according to the general procedure for the synthesis of N-Aryl-benzenesulfonamides previously described using 116 mg of (2-Amino-5-chloro-phenyl)-phenyl-methanone and 121 mg of 4-Pyrazol-1-yl-benzenesulfonyl chloride. 1H-NMR (400 MHz, CDCl3): δ 6.47 (m, 1H), 7.25 (m, 2H), 7.30-7.35 (m, 3H), 7.41 (m, 1H), 7.49-7.55 (m, 3H), 7.67-7.72 (m, 3H), 7.75-7.78 (m, 2H), 9.62 (s, 1H). MS: m/z 438.9 (M++1).

Sources & evidence

ORD record
ord-139d607df052446e816382944007e7d6
Source dataset
uspto-grants-2010_06
Patent number
US07741519B2

Reaction notes

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